Efficacy of betamethasone, hyaluronidase and its combination on mouth opening, burning sensation and QOL in patients with OSF

Efficacy of betamethasone, hyaluronidase and its combination on mouth opening, burning sensation and QOL in patients with OSF

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Objectives: To assess the efficacy of betamethasone, hyaluronidase and its combination on mouth opening, burning sensation and quality of life (QOL) in patients with oral submucous fibrosis.Study design: Sixty patients were divided in 4 groups; group A received 8 mg of betamethasone, group B received 3000 IU E-Z REST PETS of hyaluronidase, group C received the combination of betamethasone and hyaluronidase and group D received saline injections biweekly for 5 weeks.Patients were also assessed using QOL questionnaire.Results: Mouth opening and oral burning of the four groups for final visit, using the pretreatment opening as a covariate showed significant difference for group A, B, C.Conclusion: Betamethasone and hyaluronidase injections appears to be a viable option to increase mouth opening with Pastry Bags reduction in burning sensation.